SRP funded Postdoctoral Researcher to the research project Mitochondrial quality control in type 2 diabetes

Do you want to contribute to top quality medical research? Overview of the Position
The Strategic Research Programme in Diabetes (SRP Diabetes) at Karolinska Institutet is funding a prestigious fellowship programme for postdoctoral research fellows. The Programme is focused on research in diabetes and its comorbidities. With this postdoctoral programme SRP Diabetes aims to support the next generation of exceptional young scientists within the diabetes area, including both experimental and clinical research. As part of this programme, we are looking to recruit 5 outstanding postdoctoral research fellows. Full details on each project and contact information to the PIs can be found at:http://ki.se/en/srp-diabetes/postdoctoral-fellowships

Based at Karolinska Institutet, fellows will undertake a cutting-edge research project in a competitive lab and be part of the SRP Diabetes dynamic research environment where several events will be held throughout the year such as high-profile lectures, symposia, internal retreat, etc. giving the fellows lot of opportunities to make new connections both within Karolinska Institutet and internationally within the field of diabetes and metabolism.

The fellowships are fully funded, and salary is provided for a 2-year period. It is our intention that the positions will start in the fall 2026, though some flexibility with the start date might be possible.

Short running title of project: Mitochondrial quality control in type 2 diabetes

Research Project: Role of optineurin in mitochondrial quality control and metabolic flexibility in type 2 diabetes

A hallmark feature of type 2 diabetes is reduced skeletal muscle mitochondrial content. Exercise improves mitochondrial volume and quality, however emerging evidence from our laboratory suggests that this may be compromised in individuals with type 2 diabetes. The purpose of this project is to define the molecular mechanisms underlying defective mitophagy in type 2 diabetes. By using exercise as a physiological perturbation, this work will establish how mitochondrial quality control is regulated in human skeletal muscle, and how this regulation is altered in type 2 diabetes. Specifically, this project will investigate whether the mitophagy receptor optineurin contributes to exercise-stimulated mitochondrial quality control and metabolic flexibility in skeletal muscle. Furthermore, we will investigate how distinct optineurin phosphorylation signatures, that emerge after exercise in individuals with and without type 2 diabetes, regulate optineurin function and therefore mitophagy. These studies will define how optineurin regulates skeletal muscle mitophagy and reveal a mechanism underlying impaired mitochondrial quality control in type 2 diabetes, identifying a potential therapeutic target to restore metabolic flexibility.

Key responsibilities of the selected applicant:

• Plan, manage and conduct an agreed academic research project and associated activities.
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate.
• Develop research questions, analyse detailed and complex quantitative data from a variety of sources, and contribute original ideas for new research projects.
• Coordinate multiple aspects of work to deliver novel research data in accordance with established timelines set between you and the Principal Investigator.
• Adapt existing and develop new scientific techniques and experimental protocols to support research.
• Regularly write research articles at an international level for peer-reviewed journals, book chapters, and reviews.
• Formally present your research and represent the research group at internal, national and international conferences and meetings, either with other members of the team or alone.
• Informally present your research to the group at established meetings.
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques.

Selection Criteria
Essential

• A PhD in a medical/biological subject.
• Strong background in skeletal muscle biology, mitochondrial dynamics, or exercise physiology.
• Documented experience with cell biology and/or animal physiology approaches.
• Strong analytical skills and experience in statistical analysis and data interpretation.
• The ability to manage your own academic research and associated activities.
• A strong CV, having published in high impact journals and presented at international meetings.
• Ability to contribute ideas for new research projects and research income generation.
• Ability to work with meticulous attention to detail.
• An enthusiastic interest in diabetes research.
• Evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way and the ability to confidently and effectively interact with colleagues and the broader research community.
• Strong verbal and written communication skills in English.
• A conscientious and enthusiastic working approach.
• Excellent planning, organizational and problem-solving skills.

Desirable

• Documented programming experience in R and/or Python

Each Fellowship is for two years. To be eligible for employment as a post-doctor a doctoral degree or a foreign degree deemed to be equivalent to a doctoral degree is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Working at Karolinska Institutet

For further information about working at Karolinska Institutet, rules for visa/residence permit, insurance and accommodation please see:https://staff.ki.se/international-staff

Location: Solna
Application
If you consider that you meet the selection criteria, click on theLogin and apply button on this page and follow the on-screen instructions to register as a user. You will then be required to provide information in a number of screens with your application details, relating to your skills and experience. When prompted, please provide details ofthree references. You will also be required to upload a CV and Personal Letter which explains how you meet the selection criteria for the position. The Personal Letter(maximum two pages)should explain your relevant experience which may have been gained in employment, education, or you may have taken time away from these activities as illness, military service, work for labour unions or student organisations, parental leave or similar circumstances. Your application will be judged in part on the basis of how you demonstrate that you meet the selection criteria outlined above and we are happy to consider evidence of transferable skills or experience which you may have gained outside the context of paid employment or education.

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The application is to be submitted through the Varbi recruitment system.

The closing date for applications is midnight CEST on Friday 26th June, 2026.
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