JobbSafari/Lediga jobb/Postdoctoral studies in Thymic regeneration and anti cancer immunity (scholarship)
Postdoctoral studies in Thymic regeneration and anti cancer immunity (scholarship)
Karolinska InstitutetPublicerad: 2026-06-02
Ansök senast: Öppet tillsvidare
Beskrivning
Do you want to contribute to top quality medical research?
We are looking for an ambitious postdoctoral fellow with strong human or preclinical immunology skills to join the Lemarquis group at Karolinska Institutet. Our well-funded program focuses on translational mechanisms and interventions that restore T cell immunity after cancer therapy, transplantation, and aging. We offer a fast-moving, collaborative environment at the interface of spatial biology, single-cell multi-omics, and in vivo functional immunology.
Mission
Our group studies thymic function, immune reconstitution, and regenerative mechanisms that restore naïve T cell production in humans. Our research integrates lineage tracing preclinical model with advanced cellular immunology with spatial transcriptomics and single-cell multi-omics of human samples to define regenerative circuits to develop actionable therapies. We work closely with clinical cohorts and human tissue resources, and our projects are designed to bridge mechanistic discovery with translational biomarker and therapeutic development.
You will take a leading role in ongoing projects addressing novel approaches to enhance thymic function in clinically relevant contexts (e.g. cancer therapies, allo-HCT and chemotherapy). The work includes handling of human and murine models and immune monitoring material, isolation and functional profiling of T cell subsets and/or stromal-associated immune populations, and deep phenotyping using high-parameter flow cytometry. Depending on project needs, you will also generate and analyze bulk and single-cell transcriptomic and epigenetic datasets (e.g., scRNA-seq, scATAC-seq), integrate multi-modal data, and perform in vitro assays (e.g., co-cultures, organoid/ATO-type systems where relevant) and targeted loss-/gain-of-function experiments. As this is a team effort, excellent communication skills and proven ability to work in multidisciplinary teams are essential. The postdoc is expected to drive the project forward, contribute to manuscripts and presentations, and supervise students and junior researchers when needed.
Your profile
Qualified to be a postdoctoral fellow is an applicant who has obtained a PhD (or equivalent competence) in immunology, molecular/cellular biology, bioinformatics, or a closely related discipline. Applicants who have not completed a doctorate at the end of the application period may also apply provided that all requirements for a completed degree are met before the intended start date.
Meriting
Department of Laboratory Medicine (Labmed), Karolinska Institutet, Campus Flemingsberg. The group operates in a translational immunology setting with close connections to clinical partners and core facilities for advanced cytometry and sequencing-based profiling.
Duties
Entry requirements
Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.
Location: FlemingsbergType of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.
Application process
An application must contain the following documents in English or Swedish:
KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T
The application is to be submitted on the Varbi recruitment system.
Want to make a difference? Join us and contribute to better health for all
We are looking for an ambitious postdoctoral fellow with strong human or preclinical immunology skills to join the Lemarquis group at Karolinska Institutet. Our well-funded program focuses on translational mechanisms and interventions that restore T cell immunity after cancer therapy, transplantation, and aging. We offer a fast-moving, collaborative environment at the interface of spatial biology, single-cell multi-omics, and in vivo functional immunology.
Mission
Our group studies thymic function, immune reconstitution, and regenerative mechanisms that restore naïve T cell production in humans. Our research integrates lineage tracing preclinical model with advanced cellular immunology with spatial transcriptomics and single-cell multi-omics of human samples to define regenerative circuits to develop actionable therapies. We work closely with clinical cohorts and human tissue resources, and our projects are designed to bridge mechanistic discovery with translational biomarker and therapeutic development.
You will take a leading role in ongoing projects addressing novel approaches to enhance thymic function in clinically relevant contexts (e.g. cancer therapies, allo-HCT and chemotherapy). The work includes handling of human and murine models and immune monitoring material, isolation and functional profiling of T cell subsets and/or stromal-associated immune populations, and deep phenotyping using high-parameter flow cytometry. Depending on project needs, you will also generate and analyze bulk and single-cell transcriptomic and epigenetic datasets (e.g., scRNA-seq, scATAC-seq), integrate multi-modal data, and perform in vitro assays (e.g., co-cultures, organoid/ATO-type systems where relevant) and targeted loss-/gain-of-function experiments. As this is a team effort, excellent communication skills and proven ability to work in multidisciplinary teams are essential. The postdoc is expected to drive the project forward, contribute to manuscripts and presentations, and supervise students and junior researchers when needed.
Your profile
Qualified to be a postdoctoral fellow is an applicant who has obtained a PhD (or equivalent competence) in immunology, molecular/cellular biology, bioinformatics, or a closely related discipline. Applicants who have not completed a doctorate at the end of the application period may also apply provided that all requirements for a completed degree are met before the intended start date.
Meriting
- Experience with high parameter flow cytometry.
- Experience with single-cell methods
- Experience with murine models
- Unique skills applicable to cancer immunotherapy
- Interest in translational immunology and biomarker development
- Experience with human or preclinical immunology models
- Being interested in pursuing a career in academia
Department of Laboratory Medicine (Labmed), Karolinska Institutet, Campus Flemingsberg. The group operates in a translational immunology setting with close connections to clinical partners and core facilities for advanced cytometry and sequencing-based profiling.
Duties
- Plan and execute experiments in human and preclinical immunology models relevant to thymic injury and regeneration.
- Perform high-parameter flow cytometry, sequencing and downstream analysis.
- Generate, analyze, and integrate sequencing datasets.
- Perform functional assays using in vitro organoid and stem cell culture systems.
- Contribute to manuscripts, present results, mentor junior members, collaborate across projects and with other research groups.
- Supervise trainees and contribute to shared lab responsibilities as needed.
Entry requirements
Postdoctoral scholarships may be established for foreign researchers who pursue their merit in Sweden. A foreign researcher is a person living in another country who comes to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four-year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate, or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post-doctoral education.
What do we offer?
A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Students and employees have free access to our modern gym facilities with trained staff on site.
Location: FlemingsbergType of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.
Application process
An application must contain the following documents in English or Swedish:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
- A letter of motivation
KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T
The application is to be submitted on the Varbi recruitment system.
Want to make a difference? Join us and contribute to better health for all
