Doctoral student in Clinical Genetics with focus on treatment resistance in chronic lymphocytic leukemia

Do you want to contribute to top quality medical research?
To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individual study plan. For a doctoral degree, the equivalent of four years of full-time doctoral education is required.
The research group
The position is placed in prof Richard Rosenquist Brandell's research group at the department of Molecular Medicine and Surgery (MMK). The research is focused on exploring key molecular events in hematological malignancies by applying next-generation sequencing and additional state-of-the-art technologies. The group is located at BioClinicum, and includes PhD students, postdoctoral researchers, bioinformaticians and senior scientists. The group works closely with Clinical Genetics and Genomics at Karolinska University Hospital and Clinical Genomics at Science for Life Laboratory.
The doctoral student project and the duties of the doctoral student
Resistance to contemporary therapies remains a major hurdle in the clinical management of chronic lymphocytic leukemia. By combining multi-omics data from different groups of patients responsive or resistant to targeted treatment, and mechanistic studies in cells, including CRISPR screens and spatial proteomics the project aims to decipher novel mechanisms of resistance, dependent or independent of genetic lesions.

The doctoral position is partially funded through strategic funds for doctoral education (KID funding) from Karolinska Institutet.
What do we offer?
A creative and inspiring environment full of expertise and curiosity. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. As a doctoral student you are offered an individual research project, a well-educated supervisor, a vast range of elective courses and the opportunity to work in a leading research group. Karolinska Institutet collaborates with prominent universities from all around the world, which ensures opportunities for international exchanges. You will be employed on a doctoral studentship which means that you receive a contractual salary. Employees also have access to our modern gym for free and receive reimbursements for medical care.
Eligibility requirements for doctoral education
In order to participate in the selection for a doctoral position, you must meet the following general (A) and specific (B) eligibility requirements at latest by the application deadline.

It is your responsibility to certify eligibility by following the instructions on the web page Entry requirements (eligibility) for doctoral education.

A) General eligibility requirement

You meet the general eligibility requirement for doctoral/third-cycle/PhD education if you:

have been awarded a second-cycle/advanced/master qualification (i.e. master degree), or

have satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the advanced/second-cycle/master level, or

have acquired substantially equivalent knowledge in some other way in Sweden or abroad.*

Follow the instructions on the web page Entry requirements (eligibility) for doctoral education.

*If you claim equivalent knowledge, follow the instructions on the web page Assessing equivalent knowledge for general eligibility for doctoral education.

B) Specific eligibility requirement

You meet the specific eligibility requirement for doctoral/third-cycle/PhD education if you:

- Show proficiency in English equivalent to the course English B/English 6 at Swedish upper secondary school.

Follow the instructions on the web page English language requirements for doctoral education.

Verification of your documents Karolinska Institutet checks the authenticity of your documents. Karolinska Institutet reserves the right to revoke admission if supporting documents are discovered to be fraudulent. Submission of false documents is a violation of Swedish law and is considered grounds for legal action.

(A) and (B)can only be certified by the documentation requirement for doctoral education.
Skills and personal qualities
Required:

• A master's degree in biomedicine, molecular biology, biotechnology, or a closely related field
• Documented hands-on experience in mammalian cell culture and basic molecular biology techniques, such as qPCR, cloning and flow cytometry
• Excellent oral and written communication skills in English

Desirable:

• Previous hands-on experience in cancer genomics and large-scale sequencing methods.
• Experience with R and/or Python for omics data analysis is considered a strong merit.
• Previous hands-on experience with CRISPR-based genome editing and/or CRISPR screening techniques

The successful candidate should demonstrate scientific curiosity, a strong interest in biomedical research, excellent organizational and planning skills, attention to detail, and the ability to learn new methods. The candidate should be able to work effectively both independently and collaboratively in a multidisciplinary research environment.
Terms and conditions
The doctoral student will be employed on a doctoral studentship maximum 4 years full-time.


Application process
Submit your application and supporting documents through the Varbi recruitment system. Use the button in the top right corner and follow the instructions. We prefer that your application is written in English, but you can also apply in Swedish.

Your application must contain the following documents:

- A personal letter and a curriculum vitae
- Degree projects and previous publications, if any
- Any other documentation showing the desirable skills and personal qualities described above
- Documents certifying your general eligibility (see A above)
- Documents certifying your specific eligibility (see B above)
Selection
A selection will be made among eligible applicants on the basis of the ability to benefit from doctoral education. The qualifications of the applicants will be evaluated on an overall basis.

Karolinska Institutet uses the following bases of assessment:

- Documented subject knowledge of relevance to the area of research
- Analytical skill
- Other documented knowledge or experience that may be relevant to doctoral studies in the subject.

KI applies a salary scale when setting salaries for doctoral students. All applicants will be informed when the recruitment is completed.

Read more about Richard Rosenquist Brandell's research group here.
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