Thesis work, 30 credits - Preclinical and Translation PK/PD in Obesity

Om jobbet

We are excited to offer a thesis opportunity that explores the impact of obesity on pharmacokinetics and pharmacodynamics (PK/PD) in a preclinical context, with a strong focus on translational applications for clinical development.

About AstraZeneca:
AstraZeneca is a global, science-led, patient-centred biopharmaceutical company focusing on discovering, developing, and commercialising prescription medicines for some of the world's most serious diseases. But we're more than a global leading pharmaceutical company. At AstraZeneca, we're dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.

About the Opportunity:
As a Thesis Worker at AstraZeneca, you'll find an environment that's full of unique opportunities and exciting challenges. Here, you'll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. You'll be working on a meaningful project to make an impact and deliver real value for our patients and our business.

Thesis work description:
Join our research team to investigate how obesity affects pharmacokinetics and pharmacodynamics in a preclinical context, and how these findings can be useful in a translational setting. This master thesis project addresses interesting aspects of how obesity and related comorbidities may influence drug absorption, distribution, metabolism and excretion (ADME) processes and drug efficacy across different drug modalities. The project will utilize advanced PK/PD modeling and simulation (M&S), working with both internal and external data sets, to support improved translation from preclinical to clinical applications.

Impact:
This project will harness advanced PK/PD M&S to understand how obesity and its associated comorbidities could affect ADME and drug efficacy.

Key Objectives:

• Apply PK/PD M&S to analyze and interpret preclinical and clinical data
• Study the influence of obesity on the pharmacokinetics and pharmacodynamic parameters of various drug modalities
• Deepen understanding of how obesity and related comorbidities modulate ADME processes and drug efficacy
• Support translation of research findings into potential clinical impact.

Location:

This is an on-site position requiring a minimum of three days per week in the office at AstraZeneca Gothenburg. AstraZeneca does not support with relocation/accommodation.

Structure:

Duration: Fall term 2026

Credits: 30

Essential Requirements:

• Enrolled at a Swedish university
• Enrolled in a Master's program within Biotechnology, Pharmacy, Chemistry, Mathematics or other relevant fields
• Strong interest in pharmacokinetics, pharmacodynamics, translational research and PK/PD M&S
• Strong writing and oral communication skills in English

Desirable Requirements:

• Knowledge or experience with PK/PD modelling software such as Phoenix, NONMEM, R and/or MATLAB

So, what's next?
Apply today and take the chance to be part of making a difference, making connections, and gaining the tools and experience to open doors and fulfil your potential. We can't wait to hear from you!

We welcome your application as soon as possible, but ahead of the scheduled closing date 31st March 2026. In the event that we identify suitable candidates ahead of the scheduled closing date, we reserve the right to withdraw the vacancy earlier than published.

Date Posted
11-Mar-2026
Closing Date
31-Mar-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.