Postdoctor in Rheumatology

Om jobbet

The University of Gothenburg tackles society's challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future.

At the Department of Rheumatology and Inflammation Research, at the Institute of Medicine, the main research areas are inflammation and inflammatory diseases irrespective of whether they are caused by allergies, infections or are autoimmune diseases. The aim is to investigate the underpinning mechanisms behind the inflammation. Several of our researchers also work as senior consultants at the clinics at Sahlgrenska University Hospital, which is a great advantage especially for translational research.

Professor Lill Mårtensson-Bopp, expert in B cell immunology, and Professor/Chief Physician in rheumatology Inger Gjertsson, have a long-standing collaboration where they study the significance of different B-cell populations in the pathogenesis of rheumatoid arthritis (RA). Together, they have 2 PhD students, 2 postdocs, a researcher, a guest researcher, a statistician, a research engineer, and MSc and BSc students. Lab meetings are held regularly and the department of rheumatology and inflammation research holds regular seminars. Infrastructure for clinical research, single-cell RNA/DNA studies, advanced flow cytometry, and advanced microscopy is established.

Subject area

Rheumatology

Subject area description

RA is a chronic autoimmune disease affecting 0.5-1% of the population, which can lead to disability and reduced life expectancy. Our project investigates the role of memory B cells (MBCs) in RA pathogenesis. Our recent findings highlight an unusual MBC subset (CD21- Tbet+) that correlates with disease severity. Additionally, we have noticed several other subsets, most of whose functions remain unexplored. This study aims to identify these subsets using singel-cell RNA/DNA, flow cytometry and other relevant methods to study their function by analysing for instance their gene expression profiles and antibody repertoires, as well as clinical relevance. The goal is to advance therapeutic precision in RA treatment.

Duties

Job assignments include handling of human tissues and blood, sc-RNA and V(D)J analysis, flow cytometry, cell culture, analyses using molecular biological and immunological methods. Management and analysis of data, compiling data for publication as well as applying for research funding are also included. In addition to this the assignment includes presenting results and actively participating at seminars and conferences, writing manuscripts and supervision of students.

Eligibility

To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree in a relevant subject, or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made.

In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area.

Doctoral education requires general eligibility and, where appropriate, specific eligibility as set out in the general syllabus for the subject.

Assessment criteria

To be a successful candidate you are required to have a PhD in biology, molecular biology, medicine or a closely related field, extensive knowledge in immunology, in particular human B cell immunology, excellent command and documented experience in analysing and integrating sc-RNA and V(D)J data using various programs and workflows, e.g., Cellranger, Seurat, Immcantation and advanced R programming, experience in handling and analyzing public data sets with sc-RNA/V(D)J data, knowledge of flow cytometry as well as previous experience in scientific publishing.

It is meritorious with strong knowledge of rheumatology, as well as experience in Python programming for bioinformatic analysis (e.g., pySCENIC)

You shall have the ability to perform common routine analyses in an immunological laboratory, proven experience in handling human blood and tissue samples, ability to work independently and have good interpersonal skills. You shall also have excellent knowledge of English, both spoken and written.

Great emphasis is placed on personal suitability and personal characteristics such as a structured approach, teamwork skills and good sense of initiative.

Employment

Type of employment: Fixed-term employment
Extent:100 %
Location:Gothenburg
First day of employment:as soon as possible is desirable.

Contact

Lill Mårtensson-BoppProfessor +46(0)70-3640068
lill.martensson@rheuma.gu.se

Inger Gjertsson
Professor/överläkare
+46(0)730-246725
inger.gjertsson@rheuma.gu.se

Mattias Svensson
Head of Department
+46(0)31-786 67 06
mattias.svensson@rheuma.gu.se

Unions

Union representatives at the University of Gothenburg can be found here:
https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande

Information for international applicants

Visit the webpage Join us - jobs and career (länka det kursiva) for more information on the Institute of Medicine and what opportunities we have for you. Discover our world-class research and research infrastructure, as well as what the benefits are for you and your family." https://www.gu.se/en/medicine/about-us/join-us-jobs-and-career

Application

Please attach PhD certificate with the application, if the PhD certificate has not yet been issued, it needs to be attached latest at the time when the employment decision is to be made.

Submit your application via the University of Gothenburg's recruitment portal by clicking the "Apply" button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. Applications must be received by:

Applications must be received by:25-12-30

The University promotes an inclusive and equitable work environment and values the benefits of diversity. Salaries are individually determined. According to the National Archives of Sweden, application documents must be kept for two years after the position is filled. They can be returned upon request after this period; otherwise, they will be destroyed. For this recruitment, we have already chosen our channels and therefore decline further contact from vendors or recruitment agencie.

The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.

Salaries are set individually at the University.

In accordance with the National Archives of Sweden's regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.