Modelling and Simulation PK/PD Expert
Om jobbet
Are you a passionateindividualwithexpertisein mathematical modelling and pharmacokinetics-pharmacodynamics (PK/PD)? Do you want to contribute to the development of future treatments for cardiovascular, renal, and metabolic diseases? If so, we invite you to join our Modelling & Simulation team within the Early Cardiovascular, Renal and Metabolism (CVRM) therapeutic area at AstraZeneca. This position is based at our dynamic R&D site in Gothenburg, Sweden.
Accountabilities:
As a Modelling and Simulation PK/PDexpert, you will play a key role in shaping project strategies and driving critical decisions across our drugdiscoveryportfolio. You will activelyinfluencedrug project teams, guiding the selection of targets, molecules,optimaldosing strategies, patient populations, and overall development pathways.
You will have the opportunity to design and oversee the execution of complex studies in preclinical disease models, applying advanced mathematical modelling approaches to deliver impactful PK/PD and translational insights. Yourexpertisewill enable you to synthesize data from multiple sources, predict human pharmacokinetics and pharmacodynamics, and influence the definition of efficacious exposure and dosing regimens.
In this role, you will present and defend your quantitative assessments and recommendations to internal governance and senior stakeholders, shaping critical decisions at the highest levels. You will also provide scientific leadership byinitiatingandleadingstrategic DMPKand PK/PDinnovation projects, fostering collaboration across disciplines, andrepresentingAstraZeneca's modellingexpertiseboth internally and within the broader scientific community.
Essential Skills/Experience:
Desirable Skills/Experience:
At AstraZeneca, we are driven by results and use our unique blend of science and commercial knowledge to spot opportunities and drive outcomes. We are part of an expansive healthcare ecosystem that connects key players across the entire patient journey. Our patient-first approach informseverydecision we make. We are committed to your development and believe that your best is better here. Join us and be part of a global team filled with the smartest minds.
Ready to make your mark? Apply now and be a part of our journey to redefine the future of healthcare! Welcome with your application no later thanJuly 6th, 2025.
Date Posted
30-juni-2025
Closing Date
06-juli-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Accountabilities:
As a Modelling and Simulation PK/PDexpert, you will play a key role in shaping project strategies and driving critical decisions across our drugdiscoveryportfolio. You will activelyinfluencedrug project teams, guiding the selection of targets, molecules,optimaldosing strategies, patient populations, and overall development pathways.
You will have the opportunity to design and oversee the execution of complex studies in preclinical disease models, applying advanced mathematical modelling approaches to deliver impactful PK/PD and translational insights. Yourexpertisewill enable you to synthesize data from multiple sources, predict human pharmacokinetics and pharmacodynamics, and influence the definition of efficacious exposure and dosing regimens.
In this role, you will present and defend your quantitative assessments and recommendations to internal governance and senior stakeholders, shaping critical decisions at the highest levels. You will also provide scientific leadership byinitiatingandleadingstrategic DMPKand PK/PDinnovation projects, fostering collaboration across disciplines, andrepresentingAstraZeneca's modellingexpertiseboth internally and within the broader scientific community.
Essential Skills/Experience:
PhD in pharmacokinetics, pharmacology, mathematics, or related field, with a focus on model-based PK/PD approaches, preferably in a preclinical/translational setting
Industry or academic experience inexposure-response modelling(PK/PD, NLME, PBPK and/or QSP) including hands-on experience withscriptablemodellingsoftwares(e.g., Phoenix, R, Matlab, Python,Monolix, NONMEM)
Demonstrated scientific leadership through a publicationtrack recordin relevant area
Excellent interpersonal skills and the ability to work in cross-functional teams
Excellent communication skills in English, both verbal and written
Desirable Skills/Experience:
Experience in pharmaceutical research and development
Experience inPBPK modelling(e.g.Simcypor PK-Sim)
Experience in defining quantitative modelling strategies across various therapeutic modalities (e.g., small molecules, oligonucleotides, peptides, proteins,antibodiesor cell/gene therapy)
At AstraZeneca, we are driven by results and use our unique blend of science and commercial knowledge to spot opportunities and drive outcomes. We are part of an expansive healthcare ecosystem that connects key players across the entire patient journey. Our patient-first approach informseverydecision we make. We are committed to your development and believe that your best is better here. Join us and be part of a global team filled with the smartest minds.
Ready to make your mark? Apply now and be a part of our journey to redefine the future of healthcare! Welcome with your application no later thanJuly 6th, 2025.
Date Posted
30-juni-2025
Closing Date
06-juli-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca AB
FöretagAstraZeneca AB
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