Medical Director, Kidney Disease, Early Clinical Development CVRM

Om jobbet

The Medical Director will be focused onKidney Diseaseand related conditions that impact kidney function.In this role, you will have the opportunity to work at the forefront of early clinical and translational research within CVRM. In a multidisciplinary environment, you will play a key role in progressing a rich and diverse pipeline of both small and large molecules in numerous active clinical programs.

Who We Are

In theCardiovascular, Renal & Metabolism (CVRM) Translational Medicine & Clinical Development (TSCD)department, we are investigating the underlying factors contributing to CVRM disease progression using advanced scientific methodologies and data-driven drug discovery. In this context, we are evaluating a wide range of different drug modalities from our rich CVRM portfolio of compounds across kidney disease patient populations.

TSCD is where science meets clinical drug development with a focus upon delivering innovative, early phase clinical studies and accelerating human target validation while collaborating closely with our late phase clinical development and regulatory colleagues who guide our pivotal phase 3 clinical studies.

What You Will Do

You willbe responsible formanaging and leading toearly phase I-II global clinical trialsand related clinical research projects for compounds that are targeting kidney disease, as well as serving as an expert on the design, conduct, monitoring, data interpretation, and reporting of these studies. Additionally, you will work on cross-functional teams within our TSCD group and across the broader global CVRM organization that are framing our strategies and development plans for compounds that are targeting cardiovascular diseases such as Heart Failure, as well as major metabolic disorders, such as Type 2 Diabetes, Obesity, and Metabolic Dysfunction-Associated Steatohepatitis, given that these disorders intersect with chronic kidney disease and influence disease progression.

Responsibilitiesinclude:

• Lead earlyPhaseI-II globaltrialsinkidneydisease: clinicalstrategy,protocoldesign,studyconduct,monitoring, data interpretation, andreporting,ensuringscientificintegrity, patientsafety, andregulatorycompliance.
• Provideclinicalleadershiptocross-functionalteams;integratepreclinicalinsights(targetselection,pharmacology, invivo/in vitro data)intoearly clinical plans andseamlesstransitions to latephasedevelopment.
• Contributetoregulatoryinteractionsanddocumentation(e.g.,CTAs, INDs,safetyupdates,annualreports).
• Advancethedevelopmentandvalidationofnonclinicalandsurrogateendpoints(includingimagingandbiomarkers).
• RepresentTSCDinternallyandexternallythroughpresentations,publications, andscientificforums;engagewithexternalexperts and translateinsightsintostrategyandstudy design.
• Helpevolvetrial operationsand siteengagementtoimprovespeed,quality, andinclusivity in early studies.
• CollaborateacrossCVRM on programs inheartfailure,type2 diabetes,obesity, andmetabolicdysfunction-associatedsteatohepatitis, giventheirintersectionwithkidneydisease.

Basic Qualifications:

• MD, MBBS or MD/PhDwith clinical or researchexpertise in in the treatment of kidney diseases.
• Minimum of 1 year of clinical research in academia and/or the pharmaceutical/biotechnology industry.
• Experience designing, executing,monitoring, interpreting, and overseeing safety in early clinical and translational trials preferred.
• Strongcommandofbiomarkers,surrogateendpoints, andbiostatistics,supportedby a robustpublication record.
• Well developed interpersonal skills, effective teamwork, and the ability to engage stakeholders effectively across functions, geographies, and disciplines.

Why AstraZeneca?

Here, we need leadership at every level - Physicians who not only have clinical and scientific expertise, but also the ability to build a case, engage multiple partners, and communicate effectively with different audiences. With that kind of remit comes great responsibility. We truly believe that everyone contributes with an outstanding set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximize your skills, abilities and contribution.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challengeperceptions.That'swhy we work, on average, a minimum of three days per week from the office. But thatdoesn'tmeanwe'renot flexible. We balance the expectation of being in the office while respecting individual flexibility.

Join us in our unique and bold world.

Date Posted
05-Sep-2025
Closing Date
Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.